Histamine intolerance is a condition where the body cannot break down histamine fast enough - either because the DAO enzyme is deficient, gut bacteria over-produce histamine, or both. Symptoms include headaches, skin flushing and hives, digestive cramping and bloating, diarrhea, nasal congestion, and fatigue after eating trigger foods. HIT is frequently misdiagnosed as IBS or allergies. Restoring gut microbiome balance with targeted probiotics is the most direct microbiome-based intervention.